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KMID : 0378119810080010038
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Chungnam Medical Journal
1981 Volume.8 No. 1 p.38 ~ p.44
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Effect of Picibanil on the Histogenesis of the Small Intestine in the Chick Embryo
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Abstract
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The morphologic study on the differentiation of the small intestine following the administration of Picibanil was undertaken to see some inhibitory effects of the drug as related to antitumor mechanism.
The drug picibanil 0. 15KE/egg was injected twice repeatedly into chorioallantoic sac of chick embryo on the eighth day and ninth day of development.
The number of villus, height of villus, diameter of villus and thickness of submucosa and serosa on the surface of the cross section of the intestine were measured on the tenth, eleventh, twelfth, fourteenth and sixteenth day of development.
The results were summarized as follows;
1. The chick embryos given two repeated injections of picibanil showed significant decrease in the height of the villi till the twelfth day of the development and returned to normal on the fourteenth day of the development.
2. In the thickness of the submucosa and muscle coat in the intestine of the Picibaniltreated chick embryos marked inhibitory effects were also seen on the tenth and eleventh day of the development and thereafter gradually disappeared.
3. The number and diameter of the villus and thickness of serosa showed no significant changes between control and drug-treated groups.
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